Neomycin Sulfate (cas 1405-10-3)

Comprehensive Information Table ​Category ​Details ​Chemical Name Neomycin sulfate ​CAS 1405-10-3 ​Synonyms FRADIOMYCIN SULFATE, NEOMYCIN SULFATE, BIOSOLVETERINARY, MYCIGIENT, NEOBIOTIC, NEOFRACIN ​Chemical Formula C₂₃H₄₈N₆O₁₇S ​Molecular Weight 712.72 g/mol ​EINECS 215-773-1 ​Melting Point >187°C (decomposition) ​Optical Rotation [α]²⁵/D +54° (c = 2 in H₂O) ​Bulk Density 640 kg/m³ ​Refractive Index 1.56 (C=10, H₂O) ​Appearance White to slightly yellow powder ​pH 5.0–7.5 (50 g/L, H₂O, 20°C) ​Solubility Highly soluble in water (50 mg/mL stock solution); slightly soluble in ethanol and ether ​Applications ​Antibiotic: Broad-spectrum activity against Gram-positive and Gram-negative bacteria.Cell Culture: Selective agent for neomycin-resistant cells.Research: PLC inhibitor and angiogenesis modulator. ​Quality Control – ​HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– ​Impurity Limits: ≤0.5% total impurities. ​Synthesis Pathway 1. ​Fermentation: Produced by Streptomyces fradiae under controlled conditions.2. ​Purification: Crystallization from aqueous solutions. ​Safety Information ​Toxicity: Nephrotoxicity, ototoxicity, neurotoxicity at high doses.Allergenicity: Cross-reactivity with other aminoglycosides (e.g., gentamicin).Handling: Wear gloves/goggles; avoid inhalation/skin contact. ​Storage Conditions Store at 2–8°C in airtight containers, protected from light/moisture. ​Regulatory Status Approved for veterinary and research use; restricted in cosmetics/animal feed. Key Notes For toxicology data or patents, consult PubChem/ChemSpider.