Lysophosphatidic Acid (LPA, CAS 18891-11-7)

Lysophosphatidic Acid (LPA, CAS 18891-11-7) is a simplest glycerophospholipid acting as a critical extracellular signaling molecule. Derived from phospholipase-mediated hydrolysis of phosphatidylcholine, LPA regulates cell proliferation, migration, and inflammation via G-protein-coupled receptors (LPARs). Clinically, it shows promise in wound healing, dermatology, and cardiovascular disease therapy.溶血磷脂酸（LPA，CAS 18891-11-7）是结构最简单的甘油磷脂，作为关键细胞外信号分子，通过G蛋白偶联受体（LPARs）调控细胞增殖、迁移及炎症反应。临床研究显示其在创面修复、皮肤护理及心血管疾病治疗中潜力显著。 1. Basic Information ​2. Key Physicochemical Properties ​Parameter ​Details ​Solubility Highly water-soluble; forms micelles in aqueous solutions. ​Surface Activity Amphiphilic structure enables emulsification and membrane interaction. ​Stability Stable under physiological pH (6–8); susceptible to oxidation. ​参数 ​详情 ​溶解性 高度水溶性，水溶液中可形成胶束。 ​表面活性 两亲性结构赋予其乳化及膜相互作用能力。 ​稳定性 生理pH（6–8）下稳定；易被氧化破坏。 ​3. Mechanisms of Action ​4. Applications ​5. Production & Engineering ​6. Safety & Challenges ​7. Research Frontiers ​8. Regulatory Status ​Summary LPA’s dual role as a signaling lipid and functional emulsifier positions it as a multifunctional biomolecule. While its therapeutic potential in dermatology and vascular health is well-documented, challenges in stability and cost require innovative solutions. Emerging LPAR-targeted therapies and nanotechnology applications may unlock new frontiers in precision medicine. 溶血磷脂酸（LPA）兼具信号脂质与功能乳化剂特性，是多效生物分子。尽管其在皮肤科及血管健康领域的疗效明确，稳定性与成本问题仍需突破。靶向LPAR的新型疗法及纳米技术应用或将为精准医疗开辟新方向。