Alpha-Lipoic Acid (α-Lipoic Acid) （cas 62-46-4）

Alpha-Lipoic Acid (α-Lipoic Acid) is a water- and fat-soluble antioxidant used to treat diabetic neuropathy, neurodegenerative diseases, and aging-related conditions. This article details its mechanisms, clinical applications, synthesis, and market trends.α-硫辛酸（Alpha-Lipoic Acid）是一种兼具水溶性与脂溶性的强效抗氧化剂，广泛用于糖尿病神经病变、抗衰老及美容领域。本文详述其药理机制、临床应用、合成工艺及市场动态。 ​1. Basic Information ​2. Pharmacological Mechanisms ​3. Clinical Applications ​Indication ​Application Scenario ​Efficacy Evidence Diabetic neuropathy Alleviates sensory abnormalities and pain Clinical guidelines recommend; >60% symptom relief Liver injury (hepatitis/cirrhosis) Reduces transaminases, promotes regeneration Enhanced efficacy when combined with hepatoprotectants Neurodegenerative diseases Alzheimer’s (cognitive improvement), Parkinson’s (tremor reduction) Inhibits Aβ aggregation, protects neurons Anti-aging/cosmetics Skin whitening (tyrosinase inhibition), anti-wrinkle (collagen preservation) 0.1% concentration inhibits melanin by 71.5% Cardiovascular diseases Improves endothelial function, reduces atherosclerosis risk Lowers oxidative stress markers (e.g., MDA) ​4. Synthesis and Production ​5. Safety and Precautions ​6. Research Advances ​7. Market and Policy