# Hydroxyprogesterone

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17α-Hydroxyprogesterone (cas 604-09-1)

2025-05-26

Hydroxyprogesterone (68-96-2) Comprehensive Information Table ​Category ​Details ​Chemical Name 17α-Hydroxypregn-4-en-3,20-dione ​CAS Number 68-96-2 ​Synonyms 17-Hydroxyprogesterone, 4-Pregnen-17α-ol-3,20-dione, Gestagenogador, Prodox ​Chemical Formula C₂₁H₃₀O₃ ​Molecular Weight 330.46 g/mol ​EINECS Number 200-699-4 ​Melting Point 276°C ​Boiling Point 407.89°C (estimated) ​Density 1.0998 g/cm³ (estimated) ​Solubility Slightly soluble in chloroform; practically insoluble in water ​Appearance White to off-white crystalline powder ​pKa 13.03 ± 0.60 (predicted) ​Optical Activity [α]²⁵/D +54° (c = 2 in CHCl₃) Key Applications & Pharmacological Properties Synthesis & Production Quality Control & Safety ​Parameter ​Specifications ​Purity ≥98% (HPLC) ​Impurities ≤0.5% total organic impurities ​Heavy Metals ≤10 ppm (Pb, Cd, Hg) ​Toxicity – ​LD₅₀ (mouse, oral): >5000 mg/kg– ​Reproductive Toxicity: Risk of fetal virilization ​Handling Precautions Wear gloves/face shields; avoid inhalation. Store at 2–8°C in airtight containers. Regulatory Status Research & Development For detailed toxicology data or synthesis protocols, consult regulatory databases (e.g., FDA, EMA) or specialized pharmacological references.

17α-Hydroxyprogesterone Acetate (CAS 302-23-8)

2025-05-26

17α-Hydroxyprogesterone Acetate Hydroxyprogesterone Acetate Comprehensive Information Table ​Category ​Details ​Chemical Name 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate ​CAS Number 302-23-8 ​Synonyms 17α-Acetoxy-4-pregnene-3,20-dione, Precursor of Medroxyprogesterone Acetate (MPA), 17α-Hydroxyprogesterone 17-acetate ​Chemical Formula C₂₃H₃₂O₄ ​Molecular Weight 372.5 ​EINECS Number 206-119-6 ​Melting Point 249–250°C (lit.) ​Boiling Point 421.94 ± 45.0°C (predicted) ​Density 1.0415 ± 0.1 g/cm³ (estimated) ​Storage Conditions Sealed in dry, stored at 2–8°C ​Solubility Sparingly soluble in chloroform and ethyl acetate; slightly soluble in methanol; water solubility 1.01 mg/L (20°C) ​Appearance Off-white to pale yellow solid ​Optical Activity [α]²⁵/D +190° ±5° (c = 1 in chloroform) ​Applications ​Pharmaceutical Use: Key precursor for synthesizing medroxyprogesterone acetate (MPA) and megestrol acetate (MA).Research Use: Progesterone receptor activity studies and contraceptive drug development. ​Quality Control – ​HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– ​Impurity Limits: Total impurities ≤0.5%. ​Synthesis Pathway 1. ​Hydroxylation: Introduction of 17α-hydroxyl group to progesterone via microbial or chemical methods.2. ​Acetylation: Reaction of 17α-hydroxyprogesterone with acetic anhydride to form the acetate ester. ​Price (Research Grade) 30–80/gram ​Regulatory Status Compliant with EP and USP standards; prescription use in some countries. Supplementary Notes For detailed toxicological data or formulation protocols, consult specialized pharmacological references.

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