11α-Hydroxyandrosta -1,4-dien-3,17-dione (cas 7801-18-5)

11α-Hydroxyandrosta-1,4-diene-3,17-dione Comprehensive Information Table ​Category ​Details ​Chemical Name (11α)-11-Hydroxyandrosta-1,4-dien-3,17-dione ​CAS Number 7801-18-5 ​Synonyms 11-Hydroxy-1,4-androstadiene-3,17-dione; 11α-Hydroxyandrosta-1,4-dien-3,17-dione; Androsta-1,4-diene-3,17-dione,11-hydroxy-, (11α)- ​Chemical Formula C₁₉H₂₄O₃ ​Molecular Weight 300.39 ​EINECS Number 232-256-6 ​Melting Point 190–192°C ​Boiling Point 479.0 ± 45.0°C (predicted) ​Density 1.21 ± 0.1 g/cm³ (predicted) ​pKa 14.39 ± 0.60 (predicted) ​Appearance White to off-white solid ​Solubility Sparingly soluble in chloroform, DMSO, and methanol (sonicated) ​Optical Activity [α]²⁵/D +190° ±5° (c = 1 in chloroform) ​Applications ​Pharmaceutical Intermediate: Key metabolite of testosterone; used in anti-osteoporosis drug development.Research Use: Steroid hormone metabolism studies. ​Quality Control – ​HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– ​Impurity Limits: ≤0.5% total impurities. ​Synthesis Pathway 1. ​Hydroxylation: Introduction of 11α-hydroxyl group via microbial or chemical methods (e.g., Trichoderma hamatum enzymatic transformation).2. ​Isolation: Crystallization from organic solvents. ​Key Suppliers – ​J & K Scientific (Tel: 010-82848833, China)– ​Shenzhen Polymeri Biochemical (Tel: 13296077563, China)– ​Shanghai T&W Pharmaceutical (Tel: 021-61551413, China) ​Safety Information ​Risk Statements: R36/37/38 (irritating to eyes, respiratory system, skin)Precautionary Measures: S22 (Avoid inhalation), S24/25 (Avoid contact) ​MSDS Available from suppliers Supplementary Notes For detailed toxicological data or formulation protocols, consult specialized pharmacological references (e.g., PubChem, ChemSpider).