Anecortave Acetate (H6) （cas 7753-60-8）

Comprehensive Information Table ​Category ​Details ​CAS Number 7753-60-8 ​Synonyms Retaane, Anecortave, 21-Acetoxypregna-4,9(11)-dien-17α-ol-3,20-dione, Hydrocortisone Acetate EP Impurity E ​Chemical Formula C₂₃H₃₀O₅ ​Molecular Weight 386.48 g/mol ​EINECS Number 231-812-5 ​Melting Point 230–234°C ​Solubility Slightly soluble in chloroform and methanol; practically insoluble in water ​Appearance White to off-white powder ​pKa 12.47 ± 0.60 (predicted) ​Optical Activity [α]²⁵/D +117° (c = 1.0 in CHCl₃) ​Bulk Density ~640 kg/m³ ​Refractive Index 1.56 (C=10, H₂O) Key Applications & Pharmacological Properties Synthesis & Production Quality Control & Safety ​Parameter ​Specifications ​Purity ≥98% (HPLC) ​Impurities ≤0.5% total organic impurities ​Heavy Metals ≤10 ppm (Pb, Cd, Hg) ​Toxicity – ​LD₅₀ (mouse, oral): >5000 mg/kg– ​Irritation: Eyes, respiratory system, skin ​Handling Precautions Wear gloves/face shields; avoid inhalation. Store at -20°C in airtight containers. Regulatory Status Research & Development For detailed toxicology data or synthesis protocols, consult regulatory databases (e.g., FDA, EMA) or specialized pharmacological references.