17α-Hydroxyprogesterone (cas 604-09-1)

Hydroxyprogesterone (68-96-2) Comprehensive Information Table ​Category ​Details ​Chemical Name 17α-Hydroxypregn-4-en-3,20-dione ​CAS Number 68-96-2 ​Synonyms 17-Hydroxyprogesterone, 4-Pregnen-17α-ol-3,20-dione, Gestagenogador, Prodox ​Chemical Formula C₂₁H₃₀O₃ ​Molecular Weight 330.46 g/mol ​EINECS Number 200-699-4 ​Melting Point 276°C ​Boiling Point 407.89°C (estimated) ​Density 1.0998 g/cm³ (estimated) ​Solubility Slightly soluble in chloroform; practically insoluble in water ​Appearance White to off-white crystalline powder ​pKa 13.03 ± 0.60 (predicted) ​Optical Activity [α]²⁵/D +54° (c = 2 in CHCl₃) Key Applications & Pharmacological Properties Synthesis & Production Quality Control & Safety ​Parameter ​Specifications ​Purity ≥98% (HPLC) ​Impurities ≤0.5% total organic impurities ​Heavy Metals ≤10 ppm (Pb, Cd, Hg) ​Toxicity – ​LD₅₀ (mouse, oral): >5000 mg/kg– ​Reproductive Toxicity: Risk of fetal virilization ​Handling Precautions Wear gloves/face shields; avoid inhalation. Store at 2–8°C in airtight containers. Regulatory Status Research & Development For detailed toxicology data or synthesis protocols, consult regulatory databases (e.g., FDA, EMA) or specialized pharmacological references.