11α-Hydroxyandrost-4-ene-317-dione (cas 564-33-0)
11β-Hydroxyandrost-4-ene-3,17-dione (564-33-0) Comprehensive Information Table Category Details Chemical Name (11β)-11-Hydroxyandrosta-1,4-dien-3,17-dione CAS Number 564-33-0 Synonyms 11-Hydroxyandrost-4-ene-3,17-dione; 11α-Hydroxyandrost-4-ene-3,17-dione; Androst-4-ene-3,17-dione,11-hydroxy-, (11β)- Chemical Formula C₁₉H₂₆O₃ Molecular Weight 302.41 EINECS Number 1312995-182-4 Melting Point 226–227°C Boiling Point 475.3 ± 45.0°C (predicted) Density 1.19 ± 0.1 g/cm³ (predicted) Solubility Sparingly soluble in chloroform and methanol (sonicated) Appearance Light yellow to orange solid pKa 14.49 ± 0.60 (predicted) Optical Activity [α]²⁵/D +190° ±5° (c = 1 in chloroform) Applications Diagnostic Marker: Distinguishes adrenal vs. ovarian origin of hyperandrogenism in clinical diagnostics59.Pharmaceutical Intermediate: Precursor for synthesizing corticosteroids and androgenic agents.Research Use: Investigating steroidogenesis disorders (e.g., congenital adrenal hyperplasia). Quality Control – HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– Impurity Limits: ≤0.5% total impurities. Synthesis Pathway 1. Hydroxylation: Enzymatic introduction of 11β-hydroxyl group via adrenal-derived enzymes (e.g., CYP11B1) or chemical methods.2. Crystallization: Purification from steroid-rich extracts. Safety Information Risk Statements: R36/37/38 (irritating to eyes, respiratory system, skin)Precautionary Measures: S22 (Avoid inhalation), S24/25 (Avoid contact) MSDS Available from suppliers Supplementary Notes For detailed toxicological data or diagnostic protocols, consult specialized pharmacological references (e.g., PubChem, ChemSpider).
