6-Methylene Progesterone Acetate (CAS 32634-95-0 )

6-Methylene Progesterone Acetate 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate Comprehensive Information Table ​Category ​Details ​Chemical Name 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate ​CAS Number 32634-95-0 ​Synonyms Medroxyprogesterone EP Impurity E, Megestrol acetate EP Impurity D, 6-Methylene-17α-acetoxyprogesterone ​Chemical Formula C₂₄H₃₂O₄ ​Molecular Weight 384.51 ​EINECS Number 251-133-8 ​Melting Point 248–251°C (methanol) ​Boiling Point 507.6 ± 50.0°C (predicted) ​Density 1.14 ± 0.1 g/cm³ (predicted) ​Solubility Slightly soluble in chloroform and methanol (heated); practically insoluble in water (300 µg/L at 20°C) ​Appearance White to off-white solid ​Optical Activity [α]²⁵/D +17° to +24° (c = 1 in chloroform-d) ​Storage Conditions Refrigerator (4°C) ​Key Raw Materials 3,17-Dihydroxypregn-4-ene-20-one diacetate, formaldehyde diisopropyl acetal, ethyl dichlorophosphate ​Synthesis Steps 1. Epoxidation → 2. Hydrogenation → 3. 17α-Acetylation and 6-methylation → 4. Purification ​Applications ​Pharmaceutical Use: Critical intermediate for synthesizing medroxyprogesterone acetate (MPA) and megestrol acetate (MA).Research Use: Progesterone metabolism studies and anti-tumor investigations. ​Quality Control – ​HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– ​Impurity Limits: Total impurities ≤0.5%. ​Stability 24 months (protected from light and moisture) ​Major Suppliers Hebei Hongtan Biotechnology, Wuhan Dongkangyuan Biotech, HuBei ShengBaoLai ​Price (Research Grade) 50–100/gram ​Regulatory Status Compliant with EP and USP standards; prescription use in some countries. Notes For detailed toxicological data or formulation protocols, refer to specialized pharmacological references.