19-Hydroxy-4-Androstene-3, 17-Dione (cas 510-64-5)
19-Hydroxy-4-Androstene-3, 17-Dione 19-Hydroxy-4-androstene-3,17-dione Comprehensive Information Table Category Details Chemical Name 19-Hydroxy-4-androstene-3,17-dione CAS Number 510-64-5 Synonyms 19-Hydroxyandrostendione, 4-Androsten-19-ol-3,17-dione, Androst-4-en-19-ol-3,17-dione, NSC 7423 Chemical Formula C₁₉H₂₆O₃ Molecular Weight 302.41 EINECS Number 208-116-5 Melting Point 168–169°C (lit.) Boiling Point 485.4 ± 45.0°C (predicted) Density 1.19 ± 0.1 g/cm³ (predicted) Storage Conditions Sealed in dry, Store in freezer, under -20°C Solubility Slightly soluble in chloroform and methanol Appearance Off-white to pale yellow solid Optical Activity [α]²⁵/D +190° ±5° (c = 1 in chloroform) pKa 14.90 ± 0.10 (predicted) Applications Pharmaceutical Use: Novel substituted estrogen as an aromatase inhibitor; induces neuroendocrine transdifferentiation of prostate cancer cells via an ectopic olfactory receptor.Research Use: Progesterone metabolism studies and anti-tumor investigations. Quality Control – HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– Impurity Limits: Total impurities ≤0.5%. Stability 24 months (protected from light, dry, -20°C storage) Safety Information Hazard Codes: Xi (Irritant)Risk Statements: R36/37/38 (Irritating to eyes, respiratory system, skin)Safety Measures: S22 (Avoid inhalation of dust), S24/25 (Avoid contact with skin and eyes) MSDS Material Safety Data Sheet available from suppliers Notes For detailed toxicological data or formulation protocols, refer to specialized pharmacological references.