N-t-butyl-4-Androsten-3-one-17β-Carboxamide (F6)
Used in synthesis of Finasteride (5α-reductase inhibitor)
| Name | N-T-BUTYL-4-ANDROSTEN-3-ONE-17BETA-CARBOXAMIDE |
| CAS | 131267-80-6 |
| Synonyms | Fisteride Impurity 19; F6 Finasteride Intermediate; 17β-(tert-Butylcarbamoyl)androst-4-en-3-one; N-tert-butyl-3-oxo-4-androsten-17β-carboxamide, etc. |
| Molecular Formula | C₂₄H₃₇NO₂ |
| Molecular Weight | 371.56 |
| Appearance | White to off-white solid |
| Boiling Point | 540.0 ± 50.0 °C (Predicted) |
| Density | 1.07 ± 0.1 g/cm³ (Predicted) |
| pKa | 16.10 ± 0.60 (Predicted) |
| Storage Temp. | Ambient storage (light-protected, dry) |
| Solubility | Sparingly soluble in organic solvents (e.g., DMSO, ethanol) |
| Form | Powder |
| Usage | Drug Intermediate: Used in synthesis of finasteride (5α-reductase inhibitor); Impurity Reference: Quality control in pharmaceutical analysis. |
| Synthesis | Prepared via amideification of androst-4-en-3-one with tert-butylamine using coupling agents (e.g., EDC/DCC), followed by purification (recrystallization/column chromatography). |
| Regulatory Status | Not explicitly listed (consult regional regulations for specific applications). |
Additional Notes
- Chemical Structure:
- Contains a rigid androstane skeleton with a tert-butylcarbamoyl group at the 17β position.
- Key functional groups: ketone (C=O) and amide (CONHR), influencing reactivity.
- Supplier Information:
- ≥99% purity, custom synthesis.
- ¥79–1488/g, flexible specifications.
- Safety: May cause mild irritation; handle with gloves and goggles.
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