Dexamethasone (CAS:50-02-2)
White or almost white, crystalline powder.
Raw materials And Preparation Products
[Raw materials]11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione–>Hydrogen fluoride
[Preparation Products]BECLOMETHASONE–>Desoximetasone–>1,2-Dihydro Dexamethasone
| Name | Dexamethasone |
| CAS | 50-02-2 |
| Synonyms | (11B,16A)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-PREGNA-1,4-DIENE-3,20-DIONE; Hexadecadrol; Prednisolone F; DECADRON; DEXAMETHASONUM 等 |
| EINECS (EC#) | 200-003-9 |
| Molecular Formula | C₂₂H₂₉FO₅ |
| MDL Number | MFCD00064136 |
| Molecular Weight | 392.46 |
| Appearance | White or almost white, crystalline powder |
| Melting Point | 262-264 °C |
| α (alpha) | 75° (c=1, dioxane) |
| Boiling Point | 568.2±50.0 °C |
| Density | 1.1283 g/cm³ |
| Refractive Index | 76° (C=1, Dioxane) |
| Storage Temp. | 2-8°C |
| Solubility | Ethanol: 1 mg/mL |
| Form | Powder |
| pKa | 12.13±0.70 |
| Color | Off-white |
| Stability | Stable under proper storage; incompatible with strong oxidizers, bases, acid chlorides |
| Biological Source | Synthetic (organic) |
| Usage | Glucocorticoid anti-inflammatory agent; regulates T cell survival, inhibits nitric oxide synthase |
| Merck Index | 14,2943 |
| BRN | 2066651 |
| InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| EPA Substance ID | 50-02-2 |
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