Androstenedione (4-AD) (cas 63-05-8)
- CAS NO .:63-05-8
- appearance: white or white-like powder
- content:≥ 99.0%
- Melting point:≥ 169 ℃
- loss on drying:≤ 0.50%
- packing: net weight25kg/barrel
- use: steroid hormone drug intermediate
Compound Information Table: Androstenedione (CAS 63-05-8)
| Category | Details |
|---|---|
| Name | Androstenedione |
| CAS Number | 63-05-8 |
| Synonyms | 4-AD; 3,17-Dioxo-4-androstene; Androst-4-ene-3,17-dione; DELTA4-ANDROSTENE-3,17-DIONE; Androtex |
| Molecular Formula | C₁₉H₂₆O₂ |
| Molecular Weight | 286.41 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 170–171°C (literature value) |
| Boiling Point | ~369°C (estimated) |
| Density | 1.0655 g/cm³ (estimated) |
| Refractive Index | 1.4709 (estimated) |
| Solubility | Slightly soluble in chloroform, ethanol (sonicated), methanol (sparingly) |
| Storage | -20°C freezer (controlled substance) |
| Safety | – GHS hazard codes: Xn (harmful), T (toxic), F (flammable) – Carcinogen risk (RTECS classification) |
| Regulatory | – EINECS: 200-554-5 – USP reference standard |
| Usage | – Precursor to testosterone and estrogen – Androgenic activity – Diagnostic marker for hyperandrogenemia (e.g., PCOS) |
Key Notes:
- Biological Role:
- Synthesized in the adrenal glands, ovaries, and testes, serving as a precursor for testosterone and estrogen biosynthesis.
- Elevated levels are linked to polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia.
- Clinical Applications:
- Used in clinical labs to detect hyperandrogenemia (sensitivity >90% for PCOS diagnosis).
- Metabolized via 17β-hydroxysteroid dehydrogenase (17β-HSD) to testosterone.
- Regulatory Status:
- Classified as a controlled substance in the U.S. under the Anabolic Steroid Control Act of 2004.
- Banned in sports supplements by the World Anti-Doping Agency (WADA).
- Supplier Information:
- Bulk Pricing: ~¥300–800/kg (varies by quantity and purity).
For detailed protocols (e.g., HPLC detection methods), refer to peer-reviewed studies or supplier specifications.
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