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6-Methylene Progesterone Acetate (CAS 32634-95-0 )
6-Methylene Progesterone Acetate 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate Comprehensive Information Table Category Details Chemical Name 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate CAS Number 32634-95-0 Synonyms Medroxyprogesterone EP Impurity E, Megestrol acetate EP Impurity D, 6-Methylene-17α-acetoxyprogesterone Chemical Formula C₂₄H₃₂O₄ Molecular Weight 384.51 EINECS Number 251-133-8 Melting Point 248–251°C (methanol) Boiling Point 507.6 ± 50.0°C (predicted) Density 1.14 ± 0.1 g/cm³ (predicted) Solubility Slightly soluble in chloroform and methanol (heated); practically insoluble in water (300 µg/L at 20°C) Appearance White to off-white solid Optical Activity [α]²⁵/D +17° to +24° (c = 1 in chloroform-d) Storage Conditions Refrigerator (4°C) Key Raw Materials 3,17-Dihydroxypregn-4-ene-20-one diacetate, formaldehyde diisopropyl acetal, ethyl dichlorophosphate Synthesis Steps 1. Epoxidation → 2. Hydrogenation → 3. 17α-Acetylation and 6-methylation → 4. Purification Applications Pharmaceutical Use: Critical intermediate for synthesizing medroxyprogesterone acetate (MPA) and megestrol acetate (MA).Research Use: Progesterone metabolism studies and anti-tumor investigations. Quality Control – HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm.– Impurity Limits: Total impurities ≤0.5%. Stability 24 months (protected from light and moisture) Major Suppliers Hebei Hongtan Biotechnology, Wuhan Dongkangyuan Biotech, HuBei ShengBaoLai Price (Research Grade) 50–100/gram Regulatory Status Compliant with EP and USP standards; prescription use in some countries. Notes For detailed toxicological data or formulation protocols, refer to specialized pharmacological references.
Canrenone (CAS 976-71-6)
Canrenone Ingredients Canrenone (Canrenone) Comprehensive Information Chemical Properties Pharmacological Actions and Clinical Applications Safety and Precautions Manufacturing and Quality Control Research and Market Regulatory and Storage For detailed toxicological data or clinical trial protocols, consult specialized pharmacological references.
Dehydroepiandrosterone （DHEA）(cas 53-43-0)
Dehydroepiandrosterone (DHEA) Comprehensive Information Chemical Properties Pharmacological Actions and Clinical Applications Safety and Precautions Manufacturing and Quality Control Research and Market Regulatory and Storage
Flumethasone (CAS 2135-17-3)
Flumethasone (Flumethasone) Comprehensive Information Chemical Properties Pharmacological Actions and Clinical Applications Safety and Precautions Manufacturing and Quality Control Research and Market For detailed toxicological data or formulation protocols, consult specialized pharmacological references.
Hydrocortisone Acetate （CAS 50-03-3）
Hydrocortisone Acetate Hydrocortisone Acetate (Hydrocortisone Acetate) Comprehensive Information Chemical Properties Pharmacological Actions and Clinical Applications Safety and Precautions Manufacturing and Quality Control Research and Market Regulatory and Storage For detailed toxicological data or formulation protocols, consult specialized pharmacological references.
N-t-butyl-4-Androsten-3-one-17β-Carboxamide (F6)
Used in synthesis of Finasteride (5α-reductase inhibitor) Name N-T-BUTYL-4-ANDROSTEN-3-ONE-17BETA-CARBOXAMIDE CAS 131267-80-6 Synonyms Fisteride Impurity 19; F6 Finasteride Intermediate; 17β-(tert-Butylcarbamoyl)androst-4-en-3-one; N-tert-butyl-3-oxo-4-androsten-17β-carboxamide, etc. Molecular Formula C₂₄H₃₇NO₂ Molecular Weight 371.56 Appearance White to off-white solid Boiling Point 540.0 ± 50.0 °C (Predicted) Density 1.07 ± 0.1 g/cm³ (Predicted) pKa 16.10 ± 0.60 (Predicted) Storage Temp. Ambient storage (light-protected, dry) Solubility Sparingly soluble in organic solvents (e.g., DMSO, ethanol) Form Powder Usage Drug Intermediate: Used in synthesis of finasteride (5α-reductase inhibitor);Impurity Reference: Quality control in pharmaceutical analysis. Synthesis Prepared via amideification of androst-4-en-3-one with tert-butylamine using coupling agents (e.g., EDC/DCC), followed by purification (recrystallization/column chromatography). Regulatory Status Not explicitly listed (consult regional regulations for specific applications). Additional Notes
δ-Lactone (CAS 64053-02-7)
δ-Lactone Property Table Field Value Name δ-Lactone CAS 64053-02-7 Synonyms δ-Lactone Sitolactone; (4aS,6aR,9aR,9bR)-Decahydro-6a-methylcyclopenta[f][1]benzopyran-3,7-dione; etc. EINECS (EC#) Not explicitly listed (inferred as 257-139-7 based on CAS) Molecular Formula C₁₃H₁₈O₃ Molecular Weight 222.28 Appearance White to beige powder Melting Point Not explicitly listed (estimated ~127-130°C based on similar compounds) Boiling Point 389.4 ± 42.0 °C (Predicted) Density 1.161 ± 0.06 g/cm³ (Predicted) Storage Temp. Ambient storage (refer to industrial solvent guidelines) Solubility Sparingly soluble in water; freely soluble in chloroform, DMSO, methanol Form Powder pKa Not explicitly listed (estimated ~5-6, similar to lactones) Color White to beige Safety Data GHS Classification: Irritant (Skin/Eye)Signal Word: WarningHazard Statements: H315-H319 Precautionary Statements P264-P280 (Avoid contact, wear protective equipment); P302+P352 (Rinse skin); P332+P313 (Skin irritation handling) Uses 1. Industrial Recovery: Extract δ-Lactone from mother liquor (e.g., post-catalytic reaction processing).2. Organic Synthesis: Byproduct or intermediate in palladium-catalyzed telomerization reactions.3. Flavor/Pharma Intermediate: Potential use in fragrance synthesis or drug precursor development (requires validation). Synthesis Generated via palladium-catalyzed telomerization of 1,3-butadiene with CO₂, optimized using ligands (e.g., BINAP). Regulatory Status Not explicitly listed (consult regional regulations for specific applications) Additional Notes
Abiraterone Acetate (CAS 154229-18-2)
Abiraterone Acetate Property Table Field Value Name 17-(3-pyridyl)-5,16-androstadien-3β-acetate CAS 154229-18-2 Synonyms ZYTIGA, CB 7630, Abiraterone Acetate, 3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene, etc. EINECS (EC#) 620-314-7 Molecular Formula C₂₆H₃₃NO₂ Molecular Weight 391.55 Appearance White to beige powder Melting Point 127-130 °C Boiling Point 506.7 ± 50.0 °C (Predicted) Density 1.14 ± 0.1 g/cm³ (Predicted) Refractive Index 1.583 (Predicted) Storage Temp. -20°C Freezer Solubility Slightly soluble in chloroform; sparingly soluble in DMSO and methanol Form Powder pKa 5.31 ± 0.12 (Predicted) Color White to beige Usage Non-steroidal anti-inflammatory; inhibits CYP17 enzyme (17α-hydroxylase/C17,20-lyase), used for metastatic castration-resistant prostate cancer (mCRPC) and hormone-sensitive prostate cancer (HSPC). Requires prednisone co-administration. Pharmacology Selective CYP17 inhibitor; reduces testosterone levels below castration levels. Clinical Use – Indications: mCRPC, HSPC, prostate cancer bone metastasis.– Dosage: 1000 mg/day, fasting. Side Effects Common: Hypertension, hypokalemia, edema.Severe: Hepatotoxicity (monitor ALT/AST), cardiovascular events. Synthesis Synthesized from 3β-acetoxyandrosta-5,16-diene via palladium-catalyzed coupling. Regulatory Status FDA-approved (2011), EMA-approved (2011). Key References Clinical trials (Stein et al., 2014; Richards et al., 2012; Li et al., 2012). Additional Notes
Budesonide (cas 51333-22-3)
Name Budesonide CAS 51333-22-3 Synonyms 1,4-PREGNADIEN-(R,S)-11-BETA,16-ALPHA,17,21-TETROL-3,20-DIONE CYCLIC 16,17 ACETAL; PULMICORT; RHINOCORT; Entocort CR; S-1320 等 EINECS (EC#) 257-139-7 Molecular Formula C₂₅H₃₄O₆ MDL Number MFCD00083259 Molecular Weight 430.53 Appearance White Solid Melting Point 221-232 °C (dec.) α (alpha) D25 +98.9° (c = 0.28 in methylene chloride) Boiling Point 464.79°C (rough estimate) Density 1.1046 g/cm³ (estimate) Refractive Index 1.4593 (estimate) Storage Temp. 2-8°C (避光保存) Solubility Practically insoluble in water; freely soluble in methylene chloride; sparingly soluble in ethanol (96%) Form Powder pKa 12.87 ± 0.10 (Predicted) Color White to Off-White Water Solubility 21.53 mg/L (25 °C) Usage Anti-inflammatory agent; treats asthma, COPD, Crohn’s disease, ulcerative colitis, allergic rhinitis, and nasal polyps. Merck Index 14,1468 BCS Class 2 (气雾剂), 1 (肠溶胶囊) InChIKey VOVIALXJUBGFJZ-KWVAZRHASA-N CAS Database Reference 51333-22-3
Cortisone Acetate (CAS 50-04-4)
Name Cortisone acetate CAS 50-04-4 Synonyms 17,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE 21 ACETATE; 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE; 21-acetoxypregnen-17a-ol-3,11,20-trione; KENDALL’S COMPOUND ‘E’ ACETATE 等 EINECS (EC#) 200-006-5 Molecular Formula C₂₃H₃₀O₆ MDL Number MFCD00003609 Molecular Weight 402.48 Appearance Solid Melting Point 237-240 °C (lit.) α (alpha) D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane) Boiling Point 577.3 ± 50.0 °C (Predicted) Density 1.26 ± 0.1 g/cm³ (Predicted) Refractive Index 212° (C=1, MeOH) Storage Temp. 2-8°C Solubility Practically insoluble in water; freely soluble in methylene chloride; sparingly soluble in acetone; slightly soluble in ethanol (96%) and methanol Form Solid pKa 12.32 ± 0.60 (Predicted) Color White to Off-White Stability Stable under proper storage; incompatible with strong oxidizing agents. Water Solubility 19 mg/L (25 °C) Usage Anti-inflammatory; immunosuppressant; used in treatment of adrenal insufficiency, arthritis, lupus, and allergic disorders 124 Merck Index 2539 BRN 2067543 CAS Database Reference 50-04-4