(S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane (CAS 60456-22-6)
(S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane (CAS 60456-22-6) is a chiral ketal for pharmaceutical synthesis. High enantiomeric purity enables nucleophilic substitution.. (S)-(-)-4-氯甲基-2,2-二甲基-1,3-二氧戊环（CAS 60456-22-6）是一种手性缩酮化合物，用于药物合成。高对映体纯度支持亲核取代反应。
Basic Information
- Chemical Name: (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
- CAS Number: 60456-22-6
- Molecular Formula: C₆H₁₁ClO₂
- Molecular Weight: 150.6 g/mol
- Appearance: Colorless to pale yellow transparent liquid
- Purity: 97–99% (varies by supplier)
Physical and Chemical Properties
| Property | Data/Description |
|---|---|
| Boiling Point | 63°C (37 mmHg) |
| Density | 1.103 g/mL (25°C) |
| Melting Point | Stable under 2–8°C storage |
| Solubility | Miscible with chloroform, ethyl acetate; slightly soluble in water |
| Optical Activity | α²⁴/D = -42º (neat, 24°C) |
| Flash Point | 54.5°C (closed cup) |
Applications
- Pharmaceutical Synthesis:
- Chiral building block for β-blockers (e.g., landiolol) and other drugs.
- Enables nucleophilic substitution reactions for introducing chloromethyl groups.
- Organic Chemistry:
- Precursor for protected alcohols and ketals in complex molecule assembly.
- Industrial Use:
- Intermediates in agrochemicals and polymer synthesis.
Safety Information
- Hazards:
- GHS Classification: Flammable liquid (Category 3), irritant (skin/eyes).
- Risk Statements: H226 (flammable), H315 (skin irritation), H319 (eye irritation).
- Handling:
- Store in inert atmosphere at 2–8°C; avoid acidic conditions.
- Use PPE: gloves, goggles, respiratory protection.
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