Hydrogenated Docosanoic Acid Phosphatidylcholine (CAS 97281-48-6)

Hydrogenated Docosanoic Acid Phosphatidylcholine (CAS 97281-48-6) is a hydrogenated phospholipid derived from soybean lecithin. It enhances membrane stability and emulsification, widely used in pharmaceutical liposomes, cosmetic formulations, and food emulsifiers.

氢化二十二烷酸磷脂酰胆碱（CAS 97281-48-6）是一种源自大豆卵磷脂的氢化磷脂，可增强膜稳定性和乳化性能，广泛应用于药物脂质体、化妆品配方及食品乳化剂。

1. Chemical Identity

• ​Chemical Name: Hydrogenated Docosanoic Acid Phosphatidylcholine
• ​CAS Number: 97281-48-6
• ​Molecular Formula: C₄₄H₈₈NO₈P
• ​Structure: A phospholipid with a hydrogenated docosanoic acid (C22:0) chain, glycerol backbone, phosphate group, and choline headgroup. Hydrogenation reduces unsaturated bonds, improving oxidative stability.

​2. Key Properties

• ​Appearance: White powder or viscous solution
• ​Solubility: Insoluble in water; soluble in organic solvents (chloroform, ethanol)
• ​Melting Point: ~480°C (decomposition)
• ​Stability: Resistant to oxidation due to hydrogenation; stable under neutral pH.

​3. Applications

• ​Pharmaceuticals:
  • ​Drug Delivery: Used in liposomal formulations for sustained release of hydrophobic drugs (e.g., anticancer agents).
  • ​Excipients: Enhances bioavailability and membrane permeability.
• ​Cosmetics:
  • ​Emulsifier: Stabilizes O/W emulsions in creams and lotions.
  • ​Moisturizer: Forms lamellar structures to mimic skin barrier function.
• ​Food Industry:
  • ​Stabilizer: Prevents phase separation in margarine and chocolate.

​4. Production Methods

• ​Hydrogenation: Partially hydrogenated soybean phosphatidylcholine via catalytic hydrogenation to saturate fatty acid chains.
• ​Purification: Crystallization or chromatography to achieve >90% purity.

​5. Safety & Challenges

• ​Safety: GRAS (Generally Recognized as Safe) for cosmetic and dietary use; non-toxic at ≤5% concentration.
• ​Challenges:
  • High cost of hydrogenation and purification.
  • Limited solubility in aqueous systems requires formulation adjustments.

​6. Research Frontiers

• ​Nanoemulsions: Development of hydrogenated phosphatidylcholine-based systems for enhanced topical drug delivery.
• ​Functional Modifications: Tailoring fatty acid chains (e.g., docosanoic acid) for targeted applications like anti-aging cosmetics.

​Summary

Hydrogenated docosanoic acid phosphatidylcholine combines structural stability with functional versatility, making it indispensable in pharmaceuticals, cosmetics, and food science. Ongoing research focuses on optimizing production costs and expanding applications in targeted drug delivery and barrier repair technologies.