Nefopam Hydrochloride (CAS 23327-57-3)

盐酸奈福泮（CAS 23327-57-3）是一种非阿片类中枢镇痛药，用于术后止痛和癌症疼痛，市场价格约50-150元/克。English: Nefopam Hydrochloride (CAS 23327-57-3) is a non-opioid central analgesic for postoperative and cancer pain, priced at ~¥50–150/g.

Nefopam Hydrochloride (CAS 23327-57-3) Information

1. Basic Chemical Properties

• ​Chemical Formula: C₁₇H₂₀ClNO
• ​CAS Number: 23327-57-3
• ​Molecular Weight: 289.80 g/mol
• ​Physical Properties:
  • ​Appearance: White to off-white crystalline powder (API); colorless solution (injection)
  • ​Melting Point: 238–242°C
  • ​Solubility: Slightly soluble in water (5 mg/mL), highly soluble in ethanol/chloroform
  • ​logP: 2.8

2. Applications

1. ​Pharmaceutical:
   • ​Centrally Acting Analgesic: Non-opioid, non-NSAID for postoperative pain, cancer pain, and trauma
   • ​Antispasmodic: Relieves visceral smooth muscle spasms (e.g., biliary colic, renal colic)
   • ​Anesthetic Adjunct: Enhances local anesthesia efficacy
2. ​Research:
   • ​β-Catenin Modulator: Investigated for cancer and neuropathic pain
   • ​Analytical Standard: Used in GC/MS for tramadol quantification

3. Safety & Storage

• ​Hazards:
  • ​Side Effects: Drowsiness, nausea, dizziness, sweating; rare dry mouth or rash
  • ​Contraindications: Severe cardiovascular diseases, seizures
• ​Storage:
  • Store at 2–8°C in light-resistant containers; solutions at -20°C

4. Production & Supply Chain

• ​Synthesis Methods:
  • ​One-Pot Process: Methylbenzoylbenzoic acid → acyl chloride → amination → reduction → cyclization, yield ≥79%
  • ​Key Solvent: Toluene minimizes genotoxic impurities
• ​Packaging:
  • API: 1g/foil bag, 25kg drum
  • Injection: 1ml ampoules

5. Market & Pricing

• ​Demand Drivers: Postoperative pain management and oncology applications
• ​Price Range:
  • ​API: ¥50–150/g (≥99% purity)
  • ​Tablets/Injections: ¥5–20/pack (20mg)

​盐酸奈福泮（Nefopam Hydrochloride）综合信息

1. 基本化学性质

• ​化学式：C₁₇H₂₀ClNO
• ​CAS号：23327-57-3
• ​分子量：289.80 g/mol
• ​物理性质：
  • ​外观：白色至类白色结晶性粉末（原料药）；注射液为无色澄明液体
  • ​熔点：238–242°C（原料药）
  • ​溶解性：微溶于水（5 mg/mL），易溶于乙醇、氯仿；注射液需遮光保存
  • ​logP：2.8（中等脂溶性）

2. 应用领域

1. ​医药领域：
   • ​中枢性镇痛药：非阿片类、非甾体抗炎药，用于术后止痛、癌症痛、急性外伤痛
   • ​平滑肌解痉：缓解胆道蛔虫症、输尿管结石等内脏绞痛
   • ​局部麻醉辅助：与麻醉剂联用增强镇痛效果
2. ​研究用途：
   • ​β-连环蛋白调控：用于癌症及神经病理性疼痛研究
   • ​药物分析标准品：用于气相色谱-质谱联用（GC/MS）定量检测

3. 安全与储存

• ​副作用：嗜睡、恶心、头晕、出汗；偶见口干、皮疹
• ​禁忌症：严重心血管疾病、心肌梗死、惊厥患者禁用
• ​储存条件：
  • 原料药：2–8°C避光密封；溶液需-20°C短期储存
  • 长期保存需惰性气体保护，避免吸湿

4. 生产与供应链

• ​合成方法：
  • ​一锅法工艺：以邻甲基苯甲酰苯甲酸为原料，经酰氯化、胺化、还原、环化制得，总产率≥79%
  • ​关键步骤：甲苯作为溶剂，避免基因毒性杂质生成
• ​包装规格：
  • 原料药：1g/瓶（铝箔袋）、25kg纸板桶
  • 注射液：1ml:20mg（玻璃安瓿）

5. 市场与价格

• ​需求驱动：术后镇痛及癌症疼痛管理需求稳定，医药级占主导
• ​价格范围：
  • ​医药级原料：¥50–150/g（纯度≥99%）
  • ​片剂/注射液：国产约¥5–20/盒（20mg规格），进口价格更高