Sodium Polyglutamate (sodium γ-poly-glutamic acid, γ-PGA)(CAS 28829-38-1)
Compound Information: Sodium Polyglutamate
| Category | Details |
|---|---|
| Name | Sodium Polyglutamate |
| CAS Number | 28829-38-1 |
| Synonyms | Sodium γ-Polyglutamate; γ-PGA; Natto Gum |
| EINECS Number | 201-127-6 |
| Molecular Formula | (C₅H₆NO₃Na)ₙ |
| Molecular Weight | Variable (700–1500 kDa, depending on polymerization degree) |
| Chemical Properties | |
| – Appearance | White crystalline powder or granules |
| – Solubility | Highly water-soluble; forms viscous solutions |
| – pH Stability | Stable in neutral to slightly acidic conditions |
Key Applications:
- Cosmetics & Skincare
- Humectant: Enhances hydration by forming a protective skin barrier, reducing moisture loss. Synergizes with hyaluronic acid (HA) for improved efficacy and reduced greasiness.
- Brightening: Inhibits tyrosinase activity (up to 51.5% at 0.5% concentration), reducing melanin production.
- Barrier Enhancement: Boosts natural moisturizing factors (e.g., PCA, UCA), improving skin elasticity and firmness.
- Pharmaceuticals
- Drug Delivery: Serves as a sustained-release matrix for topical formulations.
- Wound Healing: Supports tissue repair through moisturizing and anti-inflammatory effects.
- Food Industry
- Flavor Enhancer: Used as a sodium salt substitute for glutamic acid, enhancing umami taste.
- Functional Food: Added to health supplements for antioxidant and detoxification properties.
Supplier Information:
| Supplier | Details |
|---|---|
| Shanghai Yijing Industrial | Cosmetic-grade, molecular weights 700–1500 kDa, purity >98% |
| Shandong Freda Biotech | Pharmaceutical-grade, <10 kDa oligomers for enhanced bioavailability |
| Sigma-Aldrich | Research-grade, 99% purity, available in 10 g–500 g packages |
| China Suppliers: | Wuhan Xingzhongcheng, Hubei Hengjingrui Chemical |
Safety & Handling:
- GHS Classification: Not classified as hazardous under standard regulations.
- Precautions: Avoid inhalation; use in ventilated areas. Store in cool, dry conditions away from oxidizers.
Regulatory Compliance:
- EINECS: 201-127-6
- HS Code: 3913.90.00 (polymers of amino acids)
Research Insights:
- Synergy with HA: A 0.5% PGA-HM + 0.5% HA blend shows superior hydration (49.4% water retention vs. 30% for HA alone).
- Patents: Over 20 patents cover synthesis methods, including microbial fermentation and enzymatic modification.
sale@pharma-peptides.com
请到「后台-用户-个人资料」中填写个人说明。