4-methyl-2-oxovaleric acid calcium (CAS 51828-95-6)

• CAS：51828-95-6
• Indications: Treatment and prevention of chronic damage caused by protein metabolism disorders caused by renal insufficiency
• Pharmacology: Synthesis of essential amino acids

Compound Information: Ketoleucine Calcium Salt Dihydrate

​Key Applications:

1. ​Pharmaceutical Use:
   • ​Phosphate Binder: Alternative to standard phosphate binders for peritoneal dialysis patients to manage hyperphosphatemia in chronic kidney disease (CKD).
   • ​Nutritional Supplement: Supports very low-protein diets for CKD patients awaiting AV fistula surgery or dialysis training.
   • ​Anti-Inflammatory Potential: May mitigate uremic toxin accumulation and oxidative stress (preliminary studies).
2. ​Industrial Use:
   • ​Pesticide Intermediate: Precursor in agrochemical synthesis (e.g., insecticides like fenthion).
   • ​Catalyst: Used in petroleum refining (hydrocracking, desulfurization).

Safety & Handling:

• ​GHS Classification:
  • Harmful if swallowed (H302), causes skin/eye irritation (H315, H319), respiratory irritation (H335).
• ​Precautions:
  • Wear gloves, goggles, and respirators.
  • Avoid inhalation; use in well-ventilated areas.
  • Store in airtight containers away from oxidizers.

​Regulatory & Research Insights:

• ​HS Code: 2918.30.9000 (carboxylic acid derivatives).
• ​Research Applications:
  • Investigated for α-keto acid metabolism pathways, similar to α-ketoglutarate (AKG), with potential roles in anti-aging and inflammation reduction.
  • Studied for gut microbiota modulation and metabolic disorder management.

​Analytical Guidelines:

• ​Detection Method: UV-Vis spectroscopy (λmax = 243 nm in methanol).
• ​Stability Testing: Monitor moisture absorption; use desiccants during storage.