Calcium 3-methyl-2-oxobutyrate (cas 51828-94-5)

• CAS：51828-94-5
• Calciumα-ketovaline
• Molecular formula：
• Indications: Treatment and prevention of chronic damage caused by protein metabolism disorders caused by renal insufficiency
• Pharmacology: Synthesis of essential amino acids

Compound Information Table: Calcium alpha-ketovaline

​Key Notes:

1. ​Chemical Structure:
   • A ​calcium salt of 3-methyl-2-oxobutyric acid, containing a branched-chain keto acid moiety.
   • Acts as a chiral resolving agent and intermediate in pharmaceutical and agrochemical synthesis.
2. ​Applications:
   • ​Pharmaceutical Use:
     • Primary ingredient in ​compound α-keto acid tablets (e.g., “Ketosteril”), used to treat chronic renal failure (CRF) and protein metabolism disorders. Reduces urea nitrogen levels by promoting nitrogen recycling.
     • Investigated for antioxidant and anti-inflammatory properties, with potential roles in metabolic disorders and cancer therapy.
   • ​Industrial Use:
     • Catalyst in hydrogenation desulfurization and hydrocracking processes for petroleum refining.
     • Intermediate in pesticide synthesis (e.g., fenthion production).
3. ​Supplier Information:
   • ​Pricing: ~100–975/g (varies by purity and order volume).
4. ​Safety & Handling:
   • ​GHS Classification: Harmful if swallowed (H302), causes skin/eye irritation (H315, H319).
   • ​Precautions: Wear gloves and goggles; avoid inhalation.
5. ​Regulatory Status:
   • ​HS Code: 2918.30.9000 (classified under carboxylic acids with ketone functional groups).

​Analytical & Handling Guidelines:

• ​Detection: UV-Vis spectroscopy (λmax = 243 nm in methanol).
• ​Stability: Hygroscopic; protect from moisture and light.