Lenvatinib Mesylate (cas 857890-39-2)
- CAS: 857890-39-2
- Molecular formula:
- Indications: Antitumor drugs
- Pharmacology: By inhibiting the kinase activity of Vascular endothelial growth factor, inhibiting cell proliferation, thereby inhibiting tumor growth.
Compound Information: Lenvatinib Mesylate
| Category | Details |
|---|---|
| Name | Lenvatinib Mesylate |
| CAS Number | 857890-39-2 |
| Synonyms | E7080 Mesylate; Lenvatinib Methanesulfonate; 4-[3-Chloro-4-(N’-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate |
| EINECS Number | 1592732-453-0 |
| Molecular Formula | C₂₁H₁₉ClN₄O₄·CH₄O₃S |
| MDL Number | MFCD18633219 |
| MOL File | 857890-39-2.mol |
| Molecular Weight | 522.96 g/mol |
| Chemical Properties | |
| – Melting Point | >220°C (decomposition) |
| – Storage Temp. | -20°C Freezer |
| – Solubility | Slightly soluble in DMSO, slightly soluble in Methanol |
| – Form | Solid |
| – Color | White to Off-White |
| InChIKey | HWLFIUUAYLEFCT-UHFFFAOYSA-N |
| SMILES | O=C(N)C1C=C2C(N=CC=C2OC2C=C(Cl)C(NC(=O)NC3CC3)=CC=2)=CC=1OC.CS(=O)(O)=O |
Key Notes:
- Chemical Structure:
- A methanesulfonate salt of lenvatinib, a multi-kinase inhibitor targeting VEGFR, FGFR, PDGFR, KIT, and RET.
- Contains a chloro-substituted quinoline core with a urea linker for enhanced target binding.
- Pharmacological Role:
- Oral administration for advanced cancers (e.g., hepatocellular carcinoma, thyroid cancer).
- Inhibits angiogenesis and tumor metastasis via VEGFR2/3 blockade 12.
- Industrial Applications:
- API for oncology drugs, formulated as 4 mg or 10 mg capsules.
- Critical reference standard for pharmacokinetic studies.
- Safety & Handling:
- Requires controlled storage to prevent moisture-induced degradation.
- Classified as Irritant (EU H319); use PPE during handling.
- Supplier Information:
- Pricing: ~$0.5–5/g (varies by purity and order volume).
Analytical & Formulation Guidelines:
- Detection: HPLC-MS for purity and metabolite analysis.
- Stability: Stable under inert atmosphere; avoid light and humidity.
For spectral data or toxicology reports, consult PubChem or supplier technical documents.
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