Estradiene dione-3-keta（Ethylene deltenone）(cas 5571-36-8)
- CAS NO.: 5571-36-8
- appearance: white or white-like powder
- content:≥ 98.0%
- Melting point:≥ 150 ℃
- loss on drying:≤ 0.50%
- packing: net weight25kg/barrel
- use: steroid hormone drug intermediate
Compound Information: Estradiene dione-3-keta (CAS 5571-36-8)
| Category | Details |
|---|---|
| Name | Estradiene dione-3-keta |
| CAS Number | 5571-36-8 |
| Synonyms | 3-Ketal; Cyclic-3-(1,2-ethanediyl acetal)-estra-5(10),9(11)-dien-3,17-dione; (8S,13S,14S)-13-Methyl-1,2,6,7,8,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-3,2′-[1,3]dioxolan]-17(4H)-one |
| Molecular Formula | C₂₀H₂₆O₃ |
| Molecular Weight | 314.42 g/mol |
| Appearance | Off-white to light yellow crystalline solid |
| Melting Point | 152–154°C |
| Boiling Point | ~488°C (predicted) |
| Density | 1.20 g/cm³ (predicted) |
| Solubility | Sparingly soluble in chloroform (heated/sonicated), methanol (slightly); 903 μg/L in water (25°C) |
| Storage | -20°C freezer (sealed, dry) |
| Usage | – Key intermediate for mifepristone (antiprogestin) – Antiglucocorticoid steroid spirooxazole – Pharmaceutical synthesis (hormonal therapies) |
| Safety | – UN ID: 3077 – Hazard Class: 9 (Miscellaneous dangerous substances) – Pack Group: III |
Key Notes:
- Chemical Structure:
- Features a steroidal backbone with a 3-ketal group and a spiro-oxolane ring system.
- The C3-ketal enhances metabolic stability and modulates biological activity.
- Pharmacological Role:
- Acts as a precursor for mifepristone (RU-486), a progesterone receptor antagonist used in medical abortions.
- Exhibits antiglucocorticoid activity by binding to glucocorticoid receptors, counteracting cortisol effects.
- Industrial Applications:
- Critical in synthetic steroid hormone production (e.g., trenbolone, nandrolone derivatives).
- Used in research for developing novel hormonal contraceptives and anti-inflammatory agents.
- Regulatory & Safety:
- Classified as a controlled substance in many countries due to anabolic steroid properties.
- Requires PPE (gloves, goggles) during handling; avoid oxidizers and strong acids.
- Supplier Information:
- Bulk Pricing: ~¥50–200/kg (varies by purity and order volume).
Analytical & Handling Guidelines:
- Detection: Requires HPLC-MS for impurity profiling in drug formulations.
- Stability: Store under inert atmosphere to prevent hydrolysis of the ketal group.
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