19-Norandrost-4-ene-3,17-dione（Norandrostenedione ）(cas 734-32-7)
- CAS NO .:734-32-7
- appearance: white or white-like crystalline powder
- content:≥ 98.0%
- Melting point:≥ 165 ℃
- loss on drying:≤ 0.50%
- packing: net weight25kg/barrel
- use: steroid hormone drug intermediate
Compound Information: Norandrostenedione (CAS 734-32-7)
| Category | Details |
|---|---|
| Name | Norandrostenedione |
| CAS Number | 734-32-7 |
| Synonyms | 19-NOR-4-ANDROSTANE-3BETA,17BETA-DIOL; 19-NOR-4-ANDROSTEN-3,17-DIONE; 4-ESTREN-3,17-DIONE; Estr-4-ene-3,17-dione |
| Molecular Formula | C₁₈H₂₄O₂ |
| Molecular Weight | 272.38 g/mol |
| Appearance | Crystalline solid |
| Melting Point | 169–172°C |
| Boiling Point | ~433°C (predicted) |
| Density | 1.13 g/cm³ (predicted) |
| Solubility | Sparingly soluble in DMF, DMSO, ethanol; 191 mg/L at 20°C (water) |
| Storage | Refrigerated (2–8°C) |
| Usage | – Intermediate for norethindrone and testosterone derivatives – Precursor in anabolic steroid synthesis |
| Safety | – Classified as a controlled substance due to anabolic steroid properties – Potential liver toxicity and hormonal imbalance risks |
| Regulatory | – EU EINECS: 211-995-8 |
Key Notes:
- Chemical Structure:
- Contains a 19-norsteroid backbone with a 4,9-diene system and a ketone group at position 3.
- Stereochemistry influences biological activity, including antiglucocorticoid effects.
- Applications:
- Primary use as a precursor for norethindrone (a synthetic progestin) and nandrolone (an anabolic steroid).
- Employed in veterinary medicine for performance-enhancing drugs (e.g., trenbolone acetate).
- Regulatory Status:
- Banned by sports authorities (e.g., IOC, NCAA) due to doping risks.
- Restricted in pharmaceutical manufacturing under controlled substance regulations.
- Supplier Information:
- Key Manufacturers: Wuhan Dongkangyuan Biotech, Nanjing Chemlin Chemical, Beijing Hubei Xinyang Medical Technology.
- Bulk Pricing: ~¥10–50/kg (varies by purity and order volume).
Analytical & Safety Guidelines:
- Detection: Requires HPLC or LC-MS for impurity profiling in drug formulations.
- Handling: Use PPE (gloves, goggles) to avoid exposure; avoid strong oxidizers and acids.
For spectral data or toxicology reports, consult PubChem or supplier technical documents.
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