19-Hydroxy-4-Androstene-3, 17-Dione (cas 510-64-5)
19-Hydroxy-4-Androstene-3, 17-Dione
19-Hydroxy-4-androstene-3,17-dione Comprehensive Information Table
| Category | Details |
|---|---|
| Chemical Name | 19-Hydroxy-4-androstene-3,17-dione |
| CAS Number | 510-64-5 |
| Synonyms | 19-Hydroxyandrostendione, 4-Androsten-19-ol-3,17-dione, Androst-4-en-19-ol-3,17-dione, NSC 7423 |
| Chemical Formula | C₁₉H₂₆O₃ |
| Molecular Weight | 302.41 |
| EINECS Number | 208-116-5 |
| Melting Point | 168–169°C (lit.) |
| Boiling Point | 485.4 ± 45.0°C (predicted) |
| Density | 1.19 ± 0.1 g/cm³ (predicted) |
| Storage Conditions | Sealed in dry, Store in freezer, under -20°C |
| Solubility | Slightly soluble in chloroform and methanol |
| Appearance | Off-white to pale yellow solid |
| Optical Activity | [α]²⁵/D +190° ±5° (c = 1 in chloroform) |
| pKa | 14.90 ± 0.10 (predicted) |
| Applications | Pharmaceutical Use: Novel substituted estrogen as an aromatase inhibitor; induces neuroendocrine transdifferentiation of prostate cancer cells via an ectopic olfactory receptor. Research Use: Progesterone metabolism studies and anti-tumor investigations. |
| Quality Control | – HPLC: C18 column, methanol-water (60:40) mobile phase, UV detection at 240 nm. – Impurity Limits: Total impurities ≤0.5%. |
| Stability | 24 months (protected from light, dry, -20°C storage) |
| Safety Information | Hazard Codes: Xi (Irritant) Risk Statements: R36/37/38 (Irritating to eyes, respiratory system, skin) Safety Measures: S22 (Avoid inhalation of dust), S24/25 (Avoid contact with skin and eyes) |
| MSDS | Material Safety Data Sheet available from suppliers |
Notes
- Structural Features: Contains a 19-hydroxy group and 3,17-dione backbone, enabling aromatase inhibition and anti-cancer activity.
- Synthesis: Requires controlled hydrogenation and crystallization steps to achieve stereochemical purity.
- Regulatory Status: Approved for research use; compliance with EP and USP standards.
For detailed toxicological data or formulation protocols, refer to specialized pharmacological references.
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