16β Methyl Epoxide (DB11) (CAS 981-34-0)

• Name: Betamethasone Epoxy Hydrolysate (DB11)
• CAS NO.: 981-34-0
• appearance: white or white-like powder
• content: 97.0% ~ 104.0%
• melting point: ≥ 240 ℃
• loss on drying: ≤ 0.50%
• packing: net weight 20kg/barrel
• use: steroid hormone drug intermediate

Compound Information: 9β,11β-Epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (CAS 981-34-0)

​Key Notes:

1. ​Chemical Structure:
   • Contains a ​9,11-epoxy ring and a ​16β-methylene group, critical for its role as a precursor in betamethasone and dexamethasone synthesis.
   • The ​3,20-diketone system enhances metabolic stability in pharmaceutical applications.
2. ​Pharmacological Role:
   • Primary intermediate for ​betamethasone (anti-inflammatory) and ​dexamethasone (immunosuppressive) synthesis.
   • Acts as a ​pharmacological reference standard for impurity profiling in corticosteroid drug manufacturing.
3. ​Industrial Applications:
   • Key raw material for synthesizing ​prednisolone, ​triamcinolone, and other corticosteroid derivatives.
   • Used in drug analysis as a quality control standard (e.g., USP, EP).
4. ​Safety & Regulations:
   • Classified as ​Irritant (EU H319) and ​Suspected Reproductive Toxicant (EU H361).
   • Requires PPE (gloves, goggles) during handling; avoid oxidizers and strong acids.
5. ​Supplier Information:
   • ​Key Manufacturers:
   • ​Bulk Pricing: ~¥1–5/g (varies by purity and order volume).

​Analytical & Handling Guidelines:

• ​Detection: Requires HPLC-MS for impurity quantification in drug formulations.
• ​Stability: Store under inert atmosphere to prevent hydrolysis of the epoxy group.