16α-Methyl Epoxide (8DM) (cas 24916-90-3)
- CAS NO .:24916-90-3
- appearance: white or white-like powder
- content:≥ 98.5%
- loss on drying:≤ 0.50%
- packing: net weight20kg/barrel
- use: steroid hormone drug intermediate
Compound Information 16-beta Methyl Epoxide (CAS 24916-90-3)
| Category | Details |
|---|---|
| Name | 16-beta Methyl Epoxide (16β-Methyl Epoxide) |
| CAS Number | 24916-90-3 |
| Synonyms | 16-ALPHA METHYL EPOXIDE; 9,11β-EPOXY-17,21-DIHYDROXY-16α-METHYL-PREGNA-1,4-DIENE-3,20-DIONE; 16β-Methyl Epoxide 21-Acetate; DB-11; 8-DM; Others listed in user data. |
| Molecular Formula | C₂₂H₂₈O₅ |
| Molecular Weight | 372.45 g/mol |
| Appearance | White to Pale Yellow Solid |
| Melting Point | 210-220°C |
| Boiling Point | 564.9 ± 50.0°C (Predicted) |
| Density | 1.32 g/cm³ |
| Flash Point | 198°C |
| Solubility | Slightly soluble in Chloroform (heated/sonicated), DMSO (sonicated), Methanol; Insoluble in water. |
| Storage | Sealed, dry, 2-8°C |
| pKa | 12.56 ± 0.70 (Predicted) |
| Color | White to Pale Yellow |
| Applications | – Metabolite of Mometasone Furoate. – Intermediate for anti-inflammatory drugs (e.g., Betamethasone). – Purity control reference for Dexamethasone. |
| Preparation | Derived from Hecogenin via epoxidation and esterification. |
| Safety | Irritant (Xi hazard code). |
| Regulatory | Compliant with hazardous material regulations (e.g., China HS Code: 2918990090). |
Key Notes:
- Molecular Formula Correction: The original data (“CH₄O”) was revised to C₂₂H₂₈O₅ based on structural analysis.
- Application Context: Critical in steroid drug synthesis (e.g., hormonal therapies).
- Supplier Information: Refer to vendors like TargetMol or Shaanxi DIDU for bulk procurement.
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